The biological fermentation workshop is characterized by a large energy consumption, which is considered to be an energy-saving measure due to the selection of production process, equipment selection layout and piping layout. Fermentation production cycle is long, and for semicontinuous process, equipment bureau and piping system design, smooth should be regulated. Distillation process with acid, alkali and organic solvent, civil engineering design needs and for fire and explosion prevention measures to prevent corrosion. In fermentation production workshop, there is a large quantity of heat and a lot of exhaust points. It is necessary to consider the measures such as natural ventilation and lighting. It is necessary to strictly control the bacteria and to sterilize the production environment regularly and replace the disinfectant. Design task of antibiotics: 17 t years working day: 300 d ShengChanBan system: three shifts a day, each class 8 h and tank units: 1050 u/mL finished product price: 590 u/mg fermentation period: 5.5 d canned material coefficient of fermentation: 0.8 second selection, production process and process design by the pharmaceutical industry mature technology: positions and process flow of three cans of bacterial species in the secondary fermentation tank after completion of training, to transplant to the fermentation tank, continue to aerate under 32-34 ℃ culture put pot after 130 h. Fermentation process, according to the actual situation of metabolism of sugar and nitrogen filling material, the fermentation 15-20 h for the first time to fill material, h around 40 second feeding, feed about 70 h for the third time to the full amount, according to the condition of metabolism, the late hydrating properly. Process pipeline and meter flow chart 3, material balance and energy balance 3.1 calculation basic data annual working days: 330d; Production shift: 3 classes, 8h per shift; Primary seed can: basic ingredients volume 1m3; Secondary seed can: basic ingredients volume 5m3;

 

    Fermentation tank: basic ingredients volume 25m3. 3.2 material balance ferment pitcher of mass balance diagram 3.3 energy balance four 4.1 equipment selection, equipment selection principle and calculation hair yeast fermentation tank pot 4.2 secondary seed and seed tank and feed tank five, the workshop layout workshop according to the technological process is divided into three working procedure, i.e. seed disinfection preparation, ingredients and fermentation, so the preparation workshop by seed, ingredients, ferment area, auxiliary area and net people changing area. The layout of the workshop should be arranged according to the process and procedure, and the natural ventilation and natural lighting measures should be taken into consideration. Follow the principle of easy operation, safe production, convenient maintenance and beautiful layout. This workshop is a class of pene plant, among which the dressing room, substation and other department are class c, and the sanitary grade is 3 and 4. 6. The rationality of the layout of the regional layout and the layout of the process equipment and the layout plan of the workshop, the design of the workshop supervisor and the piping design.